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108975 Sigma-Aldrich

Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases

Synonym: Ac-LLR-CHO, ½H₂SO₄, Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

  • CAS Number 103476-89-7

  • Empirical Formula (Hill Notation) C20H38N6O4 · 0.5H2SO4

  • Molecular Weight 475.59

  •  MDL number MFCD00037012

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Properties

Quality Level   200
assay   ≥90% (HPLC)
form   lyophilized solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
color   white
solubility   water: 50 mg/mL
shipped in   ambient
InChI   1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1
InChI key   GDBQQVLCIARPGH-ULQDDVLXSA-O

Description

General description

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).

Packaging

100 mg in Plastic ampoule

5, 10, 25 mg in Plastic ampoule

50 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
trypsin- and cysteine-like proteases

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Leu-Leu-arginal, hemisulfate

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Other Notes

Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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