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1.09684 Supelco

Formamide

for analysis EMSURE®

Synonym: Amide C1, Formic acid amide, Methane amide, Formic amide

  • CAS Number 75-12-7

  • Linear Formula HCONH2

  • Molecular Weight 45.04

  •  Beilstein/REAXYS Number 505995

  •  MDL number MFCD00007941

  •  EC Index Number 200-842-0

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Properties

Quality Level   300
vapor density   1.55 (vs air)
vapor pressure   0.08 mmHg ( 20 °C)
  30 mmHg ( 129 °C)
autoignition temp.   932 °F
potency   5325 mg/kg LD50, oral (Rat)
  17000 mg/kg LD50, skin (Rabbit)
expl. lim.   2.7-19.0 % (v/v)
refractive index   n20/D 1.447 (lit.)
pH   8-10 (20 °C, 200 g/L in H2O)
bp   210 °C (lit.)
mp   2-3 °C (lit.)
transition temp   flash point 175 °C
density   1.134 g/mL at 25 °C (lit.)
SMILES string   NC=O
InChI   1S/CH3NO/c2-1-3/h1H,(H2,2,3)
InChI key   ZHNUHDYFZUAESO-UHFFFAOYSA-N
storage conditions   Store at +2°C to +25°C.

Description

General description

EMSURE grade solvents are suitable for a broad spectrum of classical lab applications, and are frequently used in regulated and highly demanding lab applications. EMSURE provides worldwide best and most extensive product specifications. We declare our EMSURE range to be in compliance with the ACS, with the reagent part of the European Pharmacopoeia (Reag. Ph Eur) and also with the ISO standards.

Application

Formamide destabilizes nucleic acid duplexes and may be used, typically, at a concentration of 50%, in hybridization protocols requiring lower hybridization temperatures.

Analysis Note

Assay (N; Kjeldahl): ≥ 99.2 %
Identity (IR): passes test
Appearance: Clear, colorless liquid.
Colour (APHA): ≤ 10 APHA
Density (d 20 °C/ 4 °C): 1.132 - 1.135
Solidification point: 2.0 - 3.0 °C
Boiling point (2 kPa): about 103
Chloride (Cl): ≤ 1 ppm
Cd (Cadmium): ≤ 1 ppm
Cu (Copper): ≤ 1 ppm
Fe (Iron): ≤ 1 ppm
Pb (Lead): ≤ 1 ppm
Zn (Zinc): ≤ 1 ppm
Formic acid: ≤ 0.02 %
Ammonium Formate: ≤ 0.1 %
Sulfated ash (600 °C): ≤ 0.005 %
Water (according to Karl Fischer): ≤ 0.1 %

Safety & Documentation

Safety Information

Protocols & Articles

Articles

Determination of Water Content in Acrylic paint Using Karl Fischer Titration

Polymers are hardly or not at all soluble in the common Karl Fischer solvents. In order to extract the water trapped within the sample the plastic must be dissolved or swollen by means of an appropri...
Keywords: Diffusion, Karl Fischer titrations, Precipitation, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Alanine Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Amino acids Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Ammonium fluoride Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Ammonium nitrate Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Antibiotics Using Karl Fischer Titration

Pharmaceutical products are often characterized by complex formulations. Difficulties observed during Karl Fischer determination are often caused by the limited solubility. In some cases side reactio...
Keywords: Antibiotics, Karl Fischer titrations, Pharmaceutical, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Cheese Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Coffee extract (Instant coffee) Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Confectionery Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in D(+)-galactose Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in D(-)-fructose Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in D(-)-sorbit Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Disodiumhydrogenphosphate-12-hydrate Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Dry fruits Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Gelatine Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Glycine Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Hippuric acid Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Jam Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in L(+)-arabinose Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in L(-)-sorbose Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in L-Glutamine Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in L-Histidine Using Karl Fischer Titration

Most carboxylic acids can be analysed relatively easily following standard KF titration methods. Due to their weakly acidic properties they exhibit only a slight effect on the pH of the KF solution. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Lime ammonium nitrate Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Liquorice Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Magnesium chloride Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Mannitol, D-Sorbitol, Dulcitol Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Marjoram Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Marzipan Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Mashed potatoes Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Molasses Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Noodles Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Nutmeg Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Oregano Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Pepper Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Phenol urea formaldehyde resins Using Karl Fischer Titration

Polymers are hardly or not at all soluble in the common Karl Fischer solvents. In order to extract the water trapped within the sample the plastic must be dissolved or swollen by means of an appropri...
Keywords: Diffusion, Karl Fischer titrations, Precipitation, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Potassium dihydrogen fluoride Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Potassium fluoride Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Potato chips Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Rice Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Indicators, Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Saccharose (combined, total water) Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Silica gel Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Sodium chloride Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Sugar Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Sweets Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Tablet Using Karl Fischer Titration

Pharmaceutical products are often characterized by complex formulations. Difficulties observed during Karl Fischer determination are often caused by the limited solubility. In some cases side reactio...
Keywords: Karl Fischer titrations, Pharmaceutical, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Tablets Using Karl Fischer Titration

Pharmaceutical products are often characterized by complex formulations. Difficulties observed during Karl Fischer determination are often caused by the limited solubility. In some cases side reactio...
Keywords: Karl Fischer titrations, Pharmaceutical, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Thyme Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Titriplex III Using Karl Fischer Titration

Salts contain water in different kinds of bonding states: adherent moisture - enclosed water - crystal water. For determination of the total water content the substance must be completely dissolved. ...
Keywords: Esterifications, Karl Fischer titrations, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Toothpaste Using Karl Fischer Titration

Cosmetics on an aqueous and alcoholic basis can be titrated without problems according to the Karl Fischer (KF) method. Due to the often high water concentration of the emulsions small samples are re...
Keywords: Cosmetics, Indicators, Karl Fischer titrations, Sample preparations, Size-exclusion chromatography, Solvents, Titrations, Volumetric Karl Fischer titrations

Determination of Water Content in Wine gums Using Karl Fischer Titration

Foodstuffs encompass the most diverse products. Depending on whether carbohydrate-rich, fatty or proteinrich substances are under investigation, different working techniques are favourable. Complex m...
Keywords: Karl Fischer titrations, Solvents, Titrations, Volumetric Karl Fischer titrations

EMSURE® Premium grade products

The EMSURE® quality grade designates our premium classical Inorganics and Solvents, which are optimized for regulated analyses and highly demanding lab applications. These products offer the highest ...
Keywords: Solvents

Solvents for Classical Analysis, Production and Purification

Just the Right Solvent for Your Application For each of your applications, you want to use solvents that perfectly fit your needs. That’s why we strive to tailor our comprehensive range of solvents t...
Keywords: Chromatography, Evaporation, Organic synthesis, Peptide synthesis, Solvents

Water Determination in Instant Coffee by Karl Fischer Titration

Foodstuffs include a very diverse group of products. Depending on whether carbohydrate-rich, fatty or protein-rich substances are under investigation, different working techniques are preferable. Com...
Bettina Straub-Jubb
Global Product Manager Titration
Keywords: Karl Fischer titrations, Size-exclusion chromatography, Titrations, Volumetric Karl Fischer titrations

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