1.14291 Supelco


isocratic grade for liquid chromatography LiChrosolv®

Synonym: ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

  • CAS Number 75-05-8

  • Linear Formula CH3CN

  • Molecular Weight 41.05

  •  Beilstein/REAXYS Number 741857

  •  MDL number MFCD00001878

  •  EC Index Number 200-835-2



Related Categories HPLC Grade Solvents, HPLC Solvents, Solvent by Application, Solvents
Quality Level   100
vapor density   1.41 (vs air)
vapor pressure   72.8 mmHg ( 20 °C)
  97 hPa ( 20 °C)
assay   ≥99.8% (GC)
form   liquid
autoignition temp.   524 °C
  973 °F
expl. lim.   16 %
application(s)   LC/MS: suitable
refractive index   n20/D 1.344 (lit.)
bp   81-82 °C (lit.)
mp   −45 °C (lit.)
transition temp   flash point 2 °C
density   0.786 g/mL at 25 °C (lit.)
SMILES string   CC#N
InChI   1S/C2H3N/c1-2-3/h1H3
storage conditions   Store at +5°C to +30°C.


General description

With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

Analysis Note

Purity (GC): ≥ 99.8 %
Identity (IR): conforms
Evaporation residue: ≤ 4.0 mg/l
Water: ≤ 0.05 %
Acidity: ≤ 0.0005 meq/g
Alkalinity: ≤ 0.0002 meq/g
Transmission (at 195 nm): ≥ 70 %
Transmission (at 200 nm): ≥ 90 %
Transmission (from 240 nm): ≥ 98 %
Filtered by 0.2 µm filter

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Protocols & Articles


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Lopinavir and Ritonavir Tablets Assay Method Following United States Pharmacopeia Monograph Guidelines Using an Ascentis C8 Column and UV Detection

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Pressure-Temperature Calculator for Solvents

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Keywords: Absorption, Chromatography, High performance liquid chromatography, Infrared spectroscopy

Solvents for Liquid Chromatography LiChrosolv®

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Keywords: Chromatography, Evaporation, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Phase transitions, Separation, Solvents

USP Dissolution Testing Method (HPLC) for Esomeprazole Magnesium Delayed Release Capsules

Esomeprazole is a proton pump inhibitor and reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. By inhibiting the functioning of this transporter, the drug prev...
Keywords: Chromatography, High performance liquid chromatography

USP Dissolution Testing Method (HPLC) for Folic Acid Tablets using a Monolith Column and UV detection

Folic acid or folate is classified as a B vitamin (B9). Folic acid is synthetically produced, and used in fortified foods and supplements. Folate is converted by humans to dihydrofolate (dihydrofolic...
Keywords: Chromatography, High performance liquid chromatography, Sample preparations, Vitamins

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