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116814 Millipore

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt - CAS 151837-09-1 - Calbiochem

A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM).

Synonym: Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V

  • CAS Number 151837-09-1

  • Empirical Formula (Hill Notation) C10H11N5O5PS · 4C6H16N

  • Molecular Weight 344.26

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase A (PKA),
packaging   5 umol in Glass bottle (116814-5UMOL)
feature productdata solubility   H₂O (20 mg/ml)
brand family   Calbiochem
form   Crystalline solid
primary target Ki   11 µM against protein kinase A
purity   ≥98% by HPLC
storage conditions   Hygroscopic
  Ok to freeze
shipped in   wet ice
storage conditions   -20C

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKA

Product does not compete with ATP.

Reversible: yes

General description

A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.

Cell permeable inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Note: 5 µmol = 2.23 mg

Note: 5 µmol = 2.23 mg.

Other Notes

Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys.420, 336.
Yokozaki, H., et al. 1992. Cancer Res.52, 2504.
Butt, E., et al. 1990. FEBS Lett.263, 47.
Dostmann, W.R., et al. 1990. J. Biol. Chem.265, 10484.
Rothermel, J.D. 1988. Biochem. J. 251, 757.
Eckstein, F. 1985. Annu. Rev. Biochem.54, 367.
de Wit, R.J., et al. 1984. Eur. J. Biochem.142, 255.
O′Brian, C.A., et al. 1982. Biochemistry21, 4371.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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