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  • 116833 - Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-2ʹ-O-Methyl-, Sodium Salt - Calbiochem

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Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-2ʹ-O-Methyl-, Sodium Salt - Calbiochem

A potent, cell-permeable, and specific activator of the exchange protein activated by cyclic AMP (EPAC).

Synonym: 8-CPT-2ʹ-O-Me-cAMP, Na, Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-2ʹ-O-Methyl-, Sodium Salt - Calbiochem

  • Empirical Formula (Hill Notation) C17H16ClN5O6PS · Na

  • Molecular Weight 507.82

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Properties

assay   ≥98% (HPLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   water: 10 mg/mL
shipped in   ambient

Description

General description

A potent, cell-permeable, and specific activator of the exchange protein activated by cyclic AMP (EPAC) (also called cAMP-guanine nucleotide-exchange factors or cAMP-GEF) in vitro and in vivo. Does not have any effect on protein kinase A (PKA). A useful tool to discriminate between EPAC and PKA. 5 µmol = 2.54 mg. λmax = 282 nm.

A potent, cell-permeable, and specific activator of the exchange protein activated by cyclic AMP (EPAC) [also called cAMP-guanine nucleotide-exchange factors (cAMP-GEF)] in vitro and in vivo. Does not have any effect on protein kinase A (PKA). A useful tool to discriminate between EPAC and PKA.

Note: 5 µmol = 2.54 mg.

Packaging

5 umol in Plastic ampoule

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kang, G., et al. 2003. J. Biol. Chem.278, 8279.
Enserink, J.M., et al. 2002. Nat. Cell Biol., 4, 901.

Legal Information

Sold under license of European Patent Application 02/077,219.0.

Safety & Documentation

Safety Information

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Documents

Certificate of Analysis (COA)

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