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118415 Sigma-Aldrich

ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM).

Synonym: Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄, ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

  • Empirical Formula (Hill Notation) C15H23N6O12P2 · NH4 · 2H2O

  • Molecular Weight 595.39

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, P to Q,
assay   ≥95% (HPLC)
form   lyophilized solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
color   white
solubility   water: 5 mg/mL
shipped in   ambient

Description

General description

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50 = 120 nM) vs. ADP-ribose (IC50 = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.

Note: 1 set = 5 x 60 µg

Packaging

1 set in Glass bottle

60 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
PARG

Product does not compete with ATP.

Reversible: no

Target IC50: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Other Notes

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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