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118502 Millipore

InSolution ATM Kinase Inhibitor

The InSolution™ ATM Kinase Inhibitor controls the biological activity of ATM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

  • Empirical Formula (Hill Notation) C21H17NO3S2

  • Molecular Weight 395.49

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
packaging   2 mg in Glass bottle (118502-2MG)
storage condition   protect from light
brand family   Calbiochem
form   Liquid
purity   ≥95% by HPLC
storage conditions   Hygroscopic
  Ok to freeze
shipped in   wet ice
storage conditions   -20C

Description

General description

A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.

Other Notes

Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA102, 5056.
Lau, A., et al. 2005. Nat. Cell Biol.7, 493.
Hickson, I., et al. 2004. Cancer Res.64, 9152.

Packaging

Packaged under inert gas

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

B

Physical form

A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118500) in DMSO.

Safety & Documentation

Safety Information

Documents

Certificate of Analysis

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Protocols & Articles
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