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124009 Sigma-Aldrich

Akt Inhibitor III - Calbiochem

The Akt Inhibitor III controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: Akt Inhibitor III - Calbiochem, SH-6

  • Empirical Formula (Hill Notation) C28H57O9P

  • Molecular Weight 568.72

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Properties

Related Categories A to C, Akt, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥98% (NMR)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   DMSO: 10 mg/mL
shipped in   ambient

Description

General description

A cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.

A phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit PKA activity.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gills, J.J., et al. 2007. J. Biol. Chem.in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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