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1.37014 SAFC

Sodium carbonate

anhydrous EMPROVE® EXPERT Ph Eur,BP,JP,NF

Synonym: Calcined soda, Carbonic acid disodium salt, Soda ash, anhydrous soda

  • CAS Number 497-19-8

  • Linear Formula Na2CO3

  • Molecular Weight 105.99

  •  Beilstein/REAXYS Number 4154566

  •  MDL number MFCD00003494

  •  EC Index Number 207-838-8

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Properties

Agency/Method   BP
  JP
  NF
  Ph. Eur.
Quality Level   500
product line   Emprove® Expert
potency   4090 mg/kg LD50, oral (Rat)
pH   11.16 (25 °C, 4 g/L in H2O)
mp   851 °C (lit.)
density   2.53 g/cm3 at 20 °C
bulk density   1100 kg/m3
SMILES string   O=C(O[Na])O[Na]
InChI   1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2
InChI key   CDBYLPFSWZWCQE-UHFFFAOYSA-L
storage conditions   Store at +2°C to +25°C.

Description

Biochem/physiol Actions

Buffer component, may be used for the removal of peripheral membrane proteins.

Analysis Note

Assay (acidimetric; dried substance): 99.5 - 100.5 %
Assay (acidimetric; calculated on dried substance): 99.5 - 100.5 %
Appearance of solution: passes test
Identity: passes test
Chloride (Cl): ≤ 0.0125 %
Sulfate (SO₄): ≤ 0.025 %
Heavy metals (as Pb): ≤ 0.001 %
As (Arsenic): ≤ 0.00031 %
Fe (Iron): ≤ 0.0050 %
Alkali hydroxides and Alkali hydrogen carbonates: passes test
Residual solvents (Ph Eur/USP/ICH): excluded by manufacturing process
Loss on drying (300 °C): ≤ 0.5 %
Endotoxins: ≤ 2.5 I.U./g
Total aerobic microbial count: ≤ 100 CFU/g
Total yeast and mould count: ≤ 100 CFU/g
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
Corresponds to Ph Eur, BP, JP, NF

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