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137116 SAFC

L-Cysteine S-sulfate sodium salt sesquihydrate


Synonym: L-Cysteine S-sulfate sodium salt sesquihydrate, S-Sulfocysteine, SCys, Sulfo-Cysteine

  • CAS Number 150465-29-5

  • Empirical Formula (Hill Notation) C3H6NNaO5S2 · 1.5H2O

  • Molecular Weight 250.23



Related Categories Biopharmaceutical Manufacturing, Biopharmaceutical Process Development and Manufacturing, Cell Culture Ingredients and Supplements for Biopharmaceutical Manufacturing More...
Quality Level   500
biological source   synthetic
product line   Emprove® Expert
form   powder or crystals
packaging   pkg of 1 kg (1371161000)
  pkg of 100 g (1371160100)
  pkg of 5 kg (1371165000)
solubility   water: soluble (Up to 1.3M (room temp))
suitability   suitable for manufacturing use (cell culture media)
storage temp.   room temp
storage conditions   Store at +15°C to +25°C.


General description

Modified amino acids are inhouse manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes.

Together with the companion product Phospho-L-Tyrosine disodium Salt disodium salt, the new modified amino acid S-Sulfocysteine sodium salt can be used as replacement for cysteine to generate highly concentrated, neutral pH feeds. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acids tyrosine and cysteine.

Features and Benefits

• Reduced complexity in fed-batch process
• High concentrations of modified cysteine in main feeds at neutral pH
• Prevention of caustic shocks in the bioreactor due to high pH feeds
• More convenient preparation process with less contamination risks
• Reduction of recombinant protein fragmentation and decrease in trisulfide bond content
• Higher feed stability at room temperature



Title: Simplification of Fed-Batch Processes Using Modified Amino Acids

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

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137119 Phospho-L-Tyrosine Disodium Salt, EMPROVE® EXPERT

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