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  • 137119 - Phospho-L-Tyrosine Disodium Salt

137119 SAFC

Phospho-L-Tyrosine Disodium Salt


Synonym: PTyr, Phospho-L-tyrosine disodium salt, Phospho-Tyrosine, Phosphotyrosine

  • CAS Number 1610350-91-8

  • Empirical Formula (Hill Notation) C9H10NNa2O6P

  • Molecular Weight 305.13



Related Categories Biopharmaceutical Manufacturing, Biopharmaceutical Process Development and Manufacturing, Cell Culture Ingredients and Supplements for Biopharmaceutical Manufacturing More...
Quality Level   500
biological source   synthetic
product line   Emprove® Expert
form   powder or crystals
packaging   pkg of 1 kg (in PE drum, 2 inner PE liners 1371191000)
  pkg of 10 kg (in PE drum, 2 inner PE liners 1371199010)
  pkg of 100 g (in PE tub, inner glas bottle 1371190100)
pH   5.5-9.0 (10 g/L in H2O)
solubility   25 g/L
  ≤70 g/L (in complex feed)
suitability   suitable for manufacturing use (cell culture)
storage temp.   no temp limit
storage conditions   Store at +2°C to +8°C.


General description

Modified amino acids are inhouse manufactured amino acid derivatives with specific properties enabling the intensification of cell culture processes.

Together with the companion product Sulfo-Cysteine sodium salt, the new modified amino acid Phospho-Tyrosine disodium salt can be used as replacement for tyrosine to generate highly concentrated, neutral pH feeds. Both modified amino acids eliminate the need for alkaline feeds, which are normally applied to ensure solubility and stability of the unmodified amino acids tyrosine and cysteine.

Features and Benefits

• Reduced complexity in fed-batch process
• High concentrations of modified tyrosine in main feeds at neutral pH
• Enhanced solubility up to 70g/l in complex feed
• Prevention of caustic shocks in the bioreactor due to high pH feeds
• More convenient preparation process with less contamination risks
• Higher feed stability at room temperature



Title: Simplification of Fed-Batch Processes Using Modified Amino Acids

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Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

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Safety Information

NONH for all modes of transport
WGK Germany 

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