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137136 SAFC

Tetrahydrofuran EMPROVE® ESSENTIAL

tetrahydrofuran processed under GMP conditions for use in pharmaceutical production

Synonym: Butylene oxide, Oxolane, Tetrahydrofuran, Tetramethylene oxide

  • CAS Number 109-99-9

  • Empirical Formula (Hill Notation) C4H8O

  • Molecular Weight 72.11

  •  Beilstein/REAXYS Number 102391

  •  MDL number MFCD00005356

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Properties

Related Categories APIs (Active Pharmaceutical Ingredients) and Excipients, Biopharmaceutical Process Development and Manufacturing, Portfolio APIs More...
vapor density   2.5 (vs air)
vapor pressure   114 mmHg ( 15 °C)
  143 mmHg ( 20 °C)
autoignition temp.   610 °F
expl. lim.   1.8-11.8 %
refractive index   n20/D 1.407 (lit.)
pH   7-8 (20 °C, 200 g/L in H2O)
bp   65-67 °C (lit.)
mp   −108 °C (lit.)
density   0.889 g/mL at 25 °C (lit.)
SMILES string   C1CCOC1
InChI   1S/C4H8O/c1-2-4-5-3-1/h1-4H2
InChI key   WYURNTSHIVDZCO-UHFFFAOYSA-N

Description

Application


Usage


Tetrahydrofuran (THF) is a versatile organic solvent for API synthesis, as a pre-cursor to polymers and it is used for several extended applications during drug manufacturing.

Scalability

Within our new Chemiflex Critical Raw Material Program we upgrade critical raw materials to GMP to fulfill highest regulatory standards to ensure product safety and reliability. This new product offers the necessary documentation and quality for late stage API manufacturing & other extended applications.

Packaging

1 L in amber glass bottle

25, 200 L in stainless steel drum

Linkage

Emprove Documentation

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Emprove® Dossiers

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What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Three document types are included with an Emprove® Program subscription:

  • Material Qualification Dossiers
  • Quality Management Dossiers
  • Operational Excellence Dossiers

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Protocols & Articles
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