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171372 Sigma-Aldrich

Amphiregulin, Human, Recombinant

Amphiregulin, Human, Recombinant, consisting of amino acids 101-198 and is expressed in E. coli. Stimulates the proliferation of various human and mouse keratinocytes.

Synonym: Schwannoma-derived growth factor (SDGF)

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Properties

Quality Level   100
assay   ≥97% (SDS-PAGE)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
impurities   <1.0 EU/μg protein Endotoxin
shipped in   ambient

Description

General description

Recombinant, human amphiregulin (AR) consisting of amino acids 101-198 and expressed in E. coli. Human amphiregulin is able to stimulate the proliferation of various human and mouse keratinocytes, mammary epithelial cells, and some fibroblasts. Shown to be an autocrine growth factor, amphiregulin is also a growth inhibitor for various tumor cells and can bind to the EGF receptor.

Packaging

100 μg in Glass bottle

Biochem/physiol Actions

ED₅₀ = 5-15 ng/ml as measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblasts.

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 0.2 µm sterile-filtered PBS, BSA.

Reconstitution

Following reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Reconstitute to 100 µg/ml in sterile PBS containing at least 0.1% human or bovine serum albumin.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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