• USA Home
  • 178251 - α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
178251 Sigma-Aldrich

α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

α₁-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

Synonym: α₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein, α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

Purchase

Properties

Related Categories Biochemicals and Reagents, D to K, Elastase, granulocyte, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (SDS-PAGE)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
solubility   water: soluble
shipped in   ambient

Description

General description

A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.

A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues. Present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase.

Packaging

1 mg in Glass bottle

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.

Preparation Note

Please refer to vial label for lot-specific volume prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Analysis Note

>=75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.

Other Notes

Coakley, R.J., et al. 2001. Am. J. Med. Sci.321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem.52, 655.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?