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189482 Sigma-Aldrich

Autocamtide-2 Related Inhibitory Peptide, Myristoylated - Calbiochem

The Autocamtide-2 Related Inhibitory Peptide, Myristoylated controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: Autocamtide-2 Related Inhibitory Peptide, Myristoylated - Calbiochem, Myristoylated AIP, Myr-N-KKALRRQGAVDAL-OH

  • Empirical Formula (Hill Notation) C78H142N22O20

  • Molecular Weight 1708.10

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Properties

Related Categories A to C, Biochemicals and Reagents, Calmodulin dependent Protein Kinase (CaM-KK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥97% (HPLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   water: 1 mg/mL
shipped in   ambient

Description

General description

This peptide corresponds to AIP (Cat. No. 189480) which has been myristoylated at the N-terminus, enhancing its cell-permeability.

This peptide corresponds to AIP (Cat. No. 189480) which has been myristoylated at the N-terminus, thus enhancing its cell-permeability.

Packaging

500 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Calmodulin-Dependent Protein Kinase (CaM Kinase)-2

Product does not compete with ATP.

Reversible: no

Target IC50: 40 nM against cam Kinase-2

Warning

Toxicity: Standard Handling (A)

Sequence

Myr-N-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gailly, P., et al. 1998. Cell Calcium 24, 293.
Ishida, A., and Fujisawa, H. 1995. J. Biol. Chem.270, 2163.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun.212, 806.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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