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189826 Sigma-Aldrich

InSolution 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines.

Synonym: Decitabine, InSolution 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem

  • CAS Number 2353-33-5

  • Empirical Formula (Hill Notation) C8H12N4O4

  • Molecular Weight 228.21

  •  MDL number MFCD00043011

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
shipped in   ambient
InChI   1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
InChI key   XAUDJQYHKZQPEU-UHFFFAOYSA-N

Description

General description

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.

Packaging

10 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Physical form

A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.

Other Notes

Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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