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191501 Sigma-Aldrich

InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3&beta.

Synonym: InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

  • CAS Number 676596-65-9

  • Empirical Formula (Hill Notation) C15H10BrN3O

  • Molecular Weight 328.16

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression, RNA-Protein Translation Inhibitors
Quality Level   100
assay   ≥94% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
shipped in   dry ice

Description

General description

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Packaging

500 μg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
GSK-3β

Reversible: yes

Target IC50: 18 nM for GSK-3&beta

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

Other Notes

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Safety & Documentation

Safety Information

Documents

Certificate of Analysis (COA)

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