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196805 Sigma-Aldrich

Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

Synonym: (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1, (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1

  • CAS Number 335165-69-0

  • Empirical Formula (Hill Notation) C19H21Br2N3O

  • Molecular Weight 467.20

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Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology More...
brand family   Calbiochem
feature productdata solubility   DMSO (10 mg/ml)
form   Off-white solid
packaging   5 mg in Plastic ampoule (196805-5MG)
primary target IC50   520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
purity   ≥95% by HPLC
shipped in   ambient
storage conditions   +2C to +8C
  Hygroscopic
  Ok to freeze
  Protect from light

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Bax-channel forming activity

Product does not compete with ATP.

Reversible: no

General description

A cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).

Other Notes

Peixoto, P., et al. 2009. Biochem J.423, 381.
Bombrun, A., et al. 2003. J. Med. Chem.46, 4365.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Carcinogenic / Teratogenic (D)

Physical form

Supplied as a trifluoroacetate salt.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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