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  • 200487 - β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem

200487 Sigma-Aldrich

β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem

The β-Amyloid Oligomer Inhibitor, K01-162 controls the biological activity of β-Amyloid Oligomer.

Synonym: β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem, AβO Inhibitor, K01-162

  • Empirical Formula (Hill Notation) C15H14BrN

  • Molecular Weight 288.18



Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  protect from light
storage conditions   +2C to +8C
color   white to off-white
solubility   DMSO: 50 mg/mL
shipped in   ambient


General description

A cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.


10 mg in Glass bottle

Packaged under inert gas


Toxicity: Standard Handling (A)

Other Notes

Hong, H-S., et al. 2010. Neurobiol. Aging31, 1690.

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