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200488 Sigma-Aldrich

InSolutionBestatin, Hydrochloride - Calbiochem

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.

Synonym: InSolutionBestatin, Hydrochloride - Calbiochem, [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl

  • Empirical Formula (Hill Notation) C16H24N2O4 · xHCl

  • Molecular Weight 308.37 (free base basis)

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Properties

Quality Level   100
assay   ≥98% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  protect from light
storage conditions   -20C
shipped in   dry ice

Description

General description

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Packaging

10 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
Metalloproteases

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Reconstitution

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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