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203325 Millipore

BMS - CAS 145626-87-5 - Calbiochem

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

Synonym: bis(2-Mercaptoethylsulfone), bis(2-Mercaptoethylsulfone)

  • CAS Number 145626-87-5

  • Empirical Formula (Hill Notation) C4H10O2S3

  • Molecular Weight 186.32

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Properties

Related Categories Biochemicals and Reagents, Molecular Biology, Protein Electrophoresis, Proteomics, Reducing Agents,
packaging   1 gm in Plastic ampoule (203325-1GM)
pKa    (1) 7.9, (2) 9.0
brand family   Calbiochem
form   White crystalline solid
purity   ≥99% by titration
shipped in   ambient
storage conditions   -20C
  Ok to freeze

Description

General description

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pKa of 7.9 and 9.0.

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.

Other Notes

Singh, R., et al. 1995. Methods Enzymol.251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem.22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem.58, 633.

Packaging

Packaged under inert gas

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

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Documents

Certificate of Analysis

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