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203401 Millipore

Bleomycin Sulfate, Streptomyces verticillus - CAS 9041-93-4 - Calbiochem

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission.

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Properties

Related Categories Antibiotics, Biochemicals and Reagents, Cell Culture, Reagents and Supplements, Spectrum of Activity More...
brand family   Calbiochem
feature productdata solubility   H₂O (20 mg/ml)
form   White to off-white solid
packaging   10 mg in Glass bottle (203401-10MG)
purity   ≥90% by HPLC (A₂ + B₂)
shipped in   ambient
storage conditions   +2C to +8C
  Hygroscopic
  Ok to freeze

Description

Biochem/physiol Actions

Potency: 1.5-2.0 U/mg

General description

A mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

Other Notes

Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem.192, 96.
Hait, W.N., et al. 1990. Cancer Res.50, 6636.
Arkin, H., et al. 1989. Cancer Res.49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem.258, 4694.
Takita, T., et al. 1968. Antibiotics21, 79.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Warning

E

Safety & Documentation

Safety Information

RTECS 
EC5991990
Protocols & Articles
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