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203701 Sigma-Aldrich

bpV(HOpic) - Calbiochem

A potent phosphotyrosine phosphatase inhibitor.

Synonym: Dipotassium Bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate (V), PTEN Inhibitor III, PTP Inhibitor XV, bpV(HOpic) - Calbiochem

  • Linear Formula K2[VO(O2)2C6H4NO3] · 4H2O

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Properties

Quality Level   100
assay   ≥70% (51V-NMR)
form   solid
potency   14 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   yellow
solubility   water: 4 mg/mL
shipped in   ambient

Description

General description

A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
PTEN

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmid, A.C., et al. 2004. FEBS Lett.566, 35.
Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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