205530 Sigma-Aldrich

CA-074 - Calbiochem

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: CA-074 - Calbiochem, Cathepsin B Inhibitor III, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

  • Empirical Formula (Hill Notation) C18H29N3O6

  • Molecular Weight 383.44



Quality Level   100
assay   ≥98% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   colorless to white
solubility   DMSO: 10 mg/mL
shipped in   ambient


General description

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).

An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).


1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

Target IC50: 2.24 nM for rat liver cathepsin B


Toxicity: Standard Handling (A)


Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

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