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205548 Sigma-Aldrich

Caffeine - CAS 58-08-2 - Calbiochem

Trimethylated xanthine that acts as a potent central nervous system stimulant.

Synonym: 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione, Caffeine - CAS 58-08-2 - Calbiochem

  • CAS Number 58-08-2

  • Empirical Formula (Hill Notation) C8H10N4O2

  • Molecular Weight 194.19

  •  MDL number MFCD00005758

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Properties

Quality Level   100
assay   ≥99% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +15C to +30C
color   white
solubility   chloroform: 50 mg/mL
shipped in   ambient
InChI   1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
InChI key   RYYVLZVUVIJVGH-UHFFFAOYSA-N

Description

General description

Trimethylated xanthine that acts as a potent central nervous system stimulant. A nonselective phosphodiesterase inhibitor. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin and topotecan in HL-60 cells.

Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925) and topotecan in HL-60 cells.

Packaging

500 g in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
Potent central nervous system stimulant

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhen, W., and Vaugha, A. T. 1995. Radiat. Res.141, 170.
Howell, L. L. 1993. Cancer Res.54, 4993.
Traganos, F., et al. 1993. Cancer Res.53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.

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Safety Information

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