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208665 Sigma-Aldrich

Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

A cell-permeable calmodulin antagonist.

Synonym: Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem, Compound R 24571

  • CAS Number 57265-65-3

  • Empirical Formula (Hill Notation) C31H23Cl7N2O

  • Molecular Weight 687.70

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors More...
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   -20C
color   white
solubility   DMSO: 10 mg/mL
  ethanol: 10 mg/mL
shipped in   ambient

Description

General description

A cell-permeable calmodulin antagonist. An analog of sepazonium that is at least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 10 nM). Inhibits voltage-gated Ca2+ channels and stimulates the release of nitric oxide in neuroblastoma cells. Also, acts as a strong inhibitor of calcium-dependent Ca2+-ATPase in erythrocytes. Known to prolong cardiac refractory period in vivo.

A cell-permeable calmodulin antagonist. At least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain calmodulin-dependent phosphodiesterase (IC50 = 10 nM). An inhibitor of voltage-gated Ca2+ channels. Stimulates the release of nitric oxide in neuroblastoma cells. Also acts as a strong non-competitive inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+-ATPase (Ki = 60 nM). Known to prolong cardiac refractoriness in vivo.

Note: easily adheres to glass in aqueous solution.

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
brain calmodulin-dependent phosphodiesterase

Product does not compete with ATP.

Reversible: no

Target IC50: 10 nM against brain calmodulin-dependent phosphodiesterase

Caution

readily adheres to glass in aqueous solution.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.

Other Notes

Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys.296, 175.
Ichikawa, M., et al. 1991. J. Membrane Biol.120, 211.
Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
Anderson, K.W., et al. 1984. J. Biol. Chem.259, 11487.
Gietzen, L., et al. 1982. Biochem. J. 207, 541.
Van Belle, H. 1981. Cell Calcium2, 483.
Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap.208, 454.

Safety & Documentation

Safety Information

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