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208670 Sigma-Aldrich

Calmodulin, His•Tag Human, Recombinant

Calmodulin, His•Tag® Human, Recombinant, is a full-length, recombinant human calmodulin fused to a His•Tag® sequence at the N-terminus. Contains four functional Ca2+-binding sites.

Synonym: Calmodulin, Human, Recombinant, Calmodulin, Human, Recombinant

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Properties

Related Categories Apoptosis and Cell Cycle, Auxiliary Proteins, Biochemicals and Reagents, Cell Biology, Cell Cycle Proteins, Antibodies and Reagents,
packaging   50 μg in Plastic ampoule (208670-50UG)
form   liquid
shipped in   wet ice
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
brand family   Calbiochem
purity   >90% by SDS-PAGE
storage conditions   = -70C

Description

General description

Full-length, recombinant human calmodulin fused to a HisTag sequence at the N-terminus. Contains four functional Ca2+-binding sites (aa 20-31; aa 56-67; aa 93-104; aa 129-140) with EF-hands (aa 7-42; aa 43-78; aa 80-115; aa 116-148); and a ubiquitination site at Lys21. This preparation is qualified for use as a substrate for protein tyrosine kinases in in vitro assays. Through its interaction with Ca2+, calmodulin mediates the control of a large number of enzymes, including protein kinases and phosphatases. It is expected to be phosphorylated at Thr44 by CaMK4. In addition, it serves as a substrate for various protein tyrosine kinases.

Other Notes

Chou, J.J., et al. 2001.Nat. Struct. Biol.8, 990.
Lennon, G., et al. 1996.Genomics33, 151.

Packaging

50 μg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Standard Handling (A)

Physical form

In PBS, 0.2% Protease Inhibitor Cocktail Set VII (Cat. No. 539138).

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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