• USA Home
  • 208722 - Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

EMAIL THIS PAGE TO A FRIEND
208722 Sigma-Aldrich

Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem

The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem, Carbobenzoxy-valinyl-phenylalaninal, MDL 28170

  • CAS Number 88191-84-8

  • Empirical Formula (Hill Notation) C22H26N2O4

  • Molecular Weight 382.45

  •  MDL number MFCD00798796

  •  NACRES NA.77

Purchase

Properties

Related Categories A to C, Biochemicals and Reagents, Calpain, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
form   lyophilized solid
potency   8 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   white
solubility   DMSO: 20 mg/mL (Use only anhydrous DMSO.)
shipped in   ambient
InChI   1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
InChI key   NGBKFLTYGSREKK-PMACEKPBSA-N

Description

General description

A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.

A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

Packaging

25 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
calpain 1, calpain 2

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Phe-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?