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208724 Sigma-Aldrich

Calpain Inhibitor IV - Calbiochem

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: Calpain Inhibitor IV - Calbiochem, Z-LLY-FMK

  • Empirical Formula (Hill Notation) C30H40FN3O6

  • Molecular Weight 557.65

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Properties

Related Categories A to C, Biochemicals and Reagents, Calpain, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
color   white to pale yellow
solubility   DMSO: 25 mg/mL
shipped in   ambient

Description

General description

A potent, cell-permeable and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k2 = 28,900 M-1s-1). Also acts as an inhibitor of cathepsin L (k2 = 680,000 M-1s-1).

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Tyr-CH₂F

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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