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208734 Sigma-Aldrich

Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem

Potent calmodulin antagonist.

Synonym: Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem, Calmodulin antagonist, CaM kinase II 290-309

  • CAS Number 115044-69-4

  • Empirical Formula (Hill Notation) C103H185N31O24S

  • Molecular Weight 2273.83

  •  MDL number MFCD00076719

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Properties

Related Categories A to C, Biochemicals and Reagents, Calmodulin dependent Protein Kinase (CaM-KK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
form   lyophilized solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
color   white
solubility   water: soluble
shipped in   ambient

Description

General description

A potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).

Potent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.

Packaging

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Calmodulin dependent Protein Kinase-2

Product does not compete with ATP.

Reversible: no

Target IC50: 52 nM against calmodulin-dependent protein kinase II

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.

Other Notes

James, P., et al. 1995. Trends Biochem. Sci.20, 38.
Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem.270, 14062.
Yazawa, M., et al. 1992. Biochemistry 31, 3171.
Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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