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CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59, CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem

  • CAS Number 140651-18-9

  • Empirical Formula (Hill Notation) C21H37N7O3

  • Molecular Weight 435.56

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Properties

Related Categories A to C, Biochemicals and Reagents, Calmodulin dependent Protein Kinase (CaM-KK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
form   semisolid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   yellow
solubility   DMSO: 10 mg/mL

Description

General description

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 µM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 µM) and GLUT4 membrane translocation (IC50 = 100 µM) in 3T3-L1 adipocytes.

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 µM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 µM) and GLUT4 membrane translocation (IC50 = 100 µM) in 3T3-L1 adipocytes.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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