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211875 Sigma-Aldrich

Captopril - CAS 62571-86-2 - Calbiochem

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).

Synonym: Captopril - CAS 62571-86-2 - Calbiochem, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225

  • CAS Number 62571-86-2

  • Empirical Formula (Hill Notation) C9H15NO3S

  • Molecular Weight 217.29

  •  MDL number MFCD00168073

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Properties

Quality Level   100
assay   ≥98% (titration)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   white to off-white
solubility   water: 1 mg/mL
shipped in   ambient
InChI   1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChI key   FAKRSMQSSFJEIM-RQJHMYQMSA-N

Description

General description

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC50= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC50 = ~ 320 nM).

An antihypertensive agent. Reversible and competitive inhibitor of LTA4 hydrolase (IC50 = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

Packaging

1 g in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
ACE

Product does not compete with ATP.

Reversible: yes

Target IC50: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Other Notes

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

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