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217720 Sigma-Aldrich

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 3-Amino-1H-pyrazolo[3,4-b]quinoxaline, Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

  • CAS Number 40254-90-8

  • Empirical Formula (Hill Notation) C9H7N5

  • Molecular Weight 185.19

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclin-Dependent Kinase (CDK), D to K,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   red
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).

A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cdk1/cyclin B, Cdk5/p25

Product does not compete with ATP.

Reversible: no

Target IC50: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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