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218708 Sigma-Aldrich

InSolution Casein Kinase II Inhibitor I - Calbiochem

The InSolution Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: InSolution Casein Kinase II Inhibitor I - Calbiochem

  • Empirical Formula (Hill Notation) C6HBr4N3

  • Molecular Weight 434.71

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Properties

Related Categories A to C, Biochemicals and Reagents, Casein Kinase G, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   +2C to +8C
shipped in   wet ice

Description

General description

A cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CK2 rat liver, human recombinant

Product competes with ATP.

Reversible: yes

Target IC50: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Physical form

A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.

Reconstitution

Following initial use, aliquot and refrigerate (4°C).

Analysis Note

Single spot by TLC

Other Notes

Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129.
Sarno, S., et al. 2003. Biochem. J.374, 639.
Sarno, S., et al. 2001. FEBS Lett.496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418."

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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