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218710 Sigma-Aldrich

Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA, Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

  • CAS Number 934358-00-6

  • Empirical Formula (Hill Notation) C9H4Br4O2

  • Molecular Weight 463.74

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Properties

Related Categories A to C, Biochemicals and Reagents, Casein Kinase G, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
form   solid
potency   110 nM IC50
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 10 mg/mL (Use only fresh DMSO.)
  ethanol: 5 mg/mL
shipped in   ambient

Description

General description

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM).

A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861).

Packaging

5 mg in Plastic Bag(s)

Biochem/physiol Actions

Cell permeable: yes

Product competes with ATP.

Reversible: no

Target Ki: 77 nM against Casein Kinase II

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Other Notes

Pagano, M.A., et al. 2006. Chembiochem8, 129

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Protocols & Articles
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