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218744 Sigma-Aldrich

Caspase-2 Inhibitor I - Calbiochem

The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym: Caspase-2 Inhibitor I - Calbiochem, Z-VD(OMe)VAD(OMe)-FMK

  • Empirical Formula (Hill Notation) C32H46FN5O11

  • Molecular Weight 695.73

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Properties

Related Categories A to C, Biochemicals and Reagents, Caspase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
  ≥95% (TLC)
form   lyophilized
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A cell-permeable and irreversible inhibitor of caspase-2 (ICH-1)

An irreversible inhibitor of caspase-2 (ICH-1).

Packaging

1 mg in Plastic ampoule

250 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
caspase-2

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH₂F*

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gregoli, P.A., and Bondurant, M.C. 1999. J. Cell Physiol. 178, 133.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Safety & Documentation

Safety Information

Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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