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218746 Sigma-Aldrich

Caspase-1 Inhibitor VI - Calbiochem

Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5.

Synonym: Caspase-1 Inhibitor VI - Calbiochem, Z-YVAD-FMK

  • Empirical Formula (Hill Notation) C31H39FN4O9

  • Molecular Weight 630.66

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Properties

Related Categories A to C, Biochemicals and Reagents, Caspase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥95% (HPLC)
  ≥95% (TLC)
form   powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   -20C
color   white
solubility   DMSO: 5 mg/mL
shipped in   ambient

Description

General description

A potent, cell-permeable and irreversible inhibitor of caspase-1 (ICE).

A potent, cell-permeable, and irreversible inhibitor of caspase-1 (ICE), caspase-4, and caspase-5.

Packaging

1 mg in Glass bottle

250 μg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Tyr-Val-Ala-Asp(OMe)-CH₂F*

Other Notes

Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Eldadah, B.A., et al. 1997. J. Neurosci. 17, 6105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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