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218860 Sigma-Aldrich

Casein Kinase II Inhibitor VIII - Calbiochem

The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, Casein Kinase II Inhibitor VIII - Calbiochem

  • Empirical Formula (Hill Notation) C18H14N2O4S

  • Molecular Weight 354.38

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Properties

Related Categories A to C, Biochemicals and Reagents, Casein Kinase G, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   100
assay   ≥99% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   DMSO: 50 mg/mL
shipped in   wet ice

Description

General description

A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α′, respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).

Packaging

10 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CK2

Reversible: yes

Secondary Target
DYRK1B, Flt-3

Target IC50: 32 and 46 nM for CK2&alpha

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Hou, Z., et al. 2012. J. Med. Chem.55, 2899.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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