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219379 Sigma-Aldrich

Cathepsin K Inhibitor II - Calbiochem

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym: Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc

  • Empirical Formula (Hill Notation) C35H51N7O8

  • Molecular Weight 697.82

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzymes, Inhibitors, and Substrates, Protease Inhibitors
packaging   1 mg in Plastic ampoule (219379-1MG)
feature productdata solubility   DMSO (1 mg/ml)
brand family   CBC
form   Lyophilized white solid
primary target Ki   6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively
purity   ≥95% by HPLC
shipped in   1
storage conditions   21
  N

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin K

Product does not compete with ATP.

Reversible: yes

General description

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

Other Notes

Wang, D., et al. 2002. Biochemistry41, 8849.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Standard Handling (A)

Sequence

Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
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