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219478 Millipore

Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem

The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine, 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine

  • CAS Number 265312-55-8

  • Empirical Formula (Hill Notation) C15H12N2O2S

  • Molecular Weight 284.33

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclin-Dependent Kinase (CDK), Kinase/Phosphatase Biology,
packaging   5 mg in Plastic ampoule (219478-5MG)
feature productdata solubility   DMSO (10 mg/ml)
brand family   Calbiochem
form   Black-purple solid
primary target IC50   6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A
purity   ≥90% by HPLC
shipped in   ambient
storage conditions   +2C to +8C
  Protect from light
  Ok to freeze

Description

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Cdk4

Product does not compete with ATP.

Reversible: no

General description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and >200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Other Notes

Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett.10, 461.

Packaging

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Standard Handling (A)

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

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Protocols & Articles
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