• USA Home
  • 219555 - Cathepsin K Substrate II, Fluorogenic - Calbiochem

EMAIL THIS PAGE TO A FRIEND
219555 Sigma-Aldrich

Cathepsin K Substrate II, Fluorogenic - Calbiochem

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

Synonym: Cathepsin K Substrate II, Fluorogenic - Calbiochem

  • Empirical Formula (Hill Notation) C40H50N14O12

  • Molecular Weight 918.91

Purchase

Properties

Related Categories Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Protease, Substrates by Enzyme More...
Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
  protect from light
storage conditions   -20C
color   bright yellow
solubility   DMSO: 5 mg/mL
fluorescence   λex 320 nm; λem 420 nm
shipped in   wet ice

Description

General description

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates. Emission Max: 420 NM, Excitation Max: 320 nM.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM-1 S-1), but not by Cathepsins B/L/S/F/H/V. Studies using WT and CatK-/- mice reveal that the substrate is not cleaved by other proteolytic enzymes present in fibroblast lysates.

An internally quenched, highly cathepsin K-selective, fluorogenic peptide substrate that is efficiently cleaved by CatK (kcat/Km = 0.426 µM⁻¹ S⁻¹), but not by Cathepsins B/L/S/F/H/V.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Abz-His-Pro-Gly~Gly-Pro-Gln-EDDnp

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lecaille, F., et al. 2003. Biochem. J.375, 307.

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?