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Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis.

Synonym: Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

  • CAS Number 17397-89-6

  • Empirical Formula (Hill Notation) C12H17NO3

  • Molecular Weight 223.27

  •  MDL number MFCD00083595

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Properties

Related Categories Antibiotics, Antifungal, Biochemicals and Reagents, D to K, Enzyme Inhibitors,
Quality Level   100
assay   ≥98% (TLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   white to off-white
solubility   DMSO: 10 mg/mL
  ethanol: 5 mg/mL
  acetone: soluble
shipped in   ambient
InChI   1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1
InChI key   GVEZIHKRYBHEFX-NQQPLRFYSA-N

Description

General description

An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.

An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.

Packaging

5 mg in Plastic ampoule

Biochem/physiol Actions

Primary Target
sterol & fatty acid biosynthesis

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Other Notes

Loftus, T.M., et al. 2000. Science288, 2379.
Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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