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219672 Sigma-Aldrich

CFTR Inhibitor III, OXO-172 - Calbiochem

The CFTR Inhibitor III, OXO-172 controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym: 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-4-thiazolidinone, OXO-172, CFTR Inhibitor III, OXO-172 - Calbiochem

  • Empirical Formula (Hill Notation) C18H10F3NO4S

  • Molecular Weight 393.34

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chloride Channel Modulators, Ion Channels, Monovalent Ion Channels,
Quality Level   100
assay   ≥95% (HPLC, NMR)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   +2C to +8C
color   off-white
solubility   ethanol: 1 mg/mL
  DMSO: 50 mg/mL
shipped in   ambient

Description

General description

A cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).

A cell-permeable CFTRinh-172 (Cat. No. 219670) 2-oxo analog that exhibits ~25-fold higher aqueous solubility than the 2-thioxo CFTRinh-172 (420 µM vs. 17 µM, respectively, in PBS with 2% DMSO at 25 °C) and great potency, albeit slightly weaker than that of CFTRinh-172, in inhibiting CFTR-mediated apical membrane chloride current upon 20 µM Forskolin (Cat. No. 344270) stimulation in CFTR-expressing FRT cells (IC50 = 1.4 µM vs. 0.38 µM with CFTRinh-172) with practically no cytotoxicity (91% of no-drug control FRT in viability assay; 48 h at 50 µM).

Packaging

10 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sonawane, N.D., and Verkman, A.S. 2008. Bioorg. Med. Chem.16, 8187.

Safety & Documentation

Safety Information

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