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219674 Sigma-Aldrich

InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

The InSolution CFTR Inhibitor-172, also referenced under CAS 307510-92-5, controls the biological activity of CFTR. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym: (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, 3-((3-Trifluoromethyl)phenyl)-5-((4-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone, (Z)-4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, CFTRinh-172 in DMSO, InSolution CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

  • CAS Number 307510-92-5

  • Empirical Formula (Hill Notation) C18H10F3NO3S2

  • Molecular Weight 409.40

  •  MDL number MFCD06411408

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  desiccated
  protect from light
storage conditions   = -70C
shipped in   dry ice
InChI   1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-
InChI key   JIMHYXZZCWVCMI-ZSOIEALJSA-N

Description

General description

A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. The solid form of this compound (Cat. No. 219670) is also available.

Packaging

5 mg in Glass bottle

Biochem/physiol Actions

Cell permeable: yes

Primary Target
CFTR ion-channel

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 50 mM (5 mg/244 µL) solution of CFTR Inhibitor-172 (Cat. No. 219670) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (70°C). Aliquots are stable for up to 3 months at -70°C.

Other Notes

Yang, H., et al. 2003. J. Biol. Chem.278, 35079.
Al-Awqati, Q., et al. 2002. J. Clin. Invest.110, 1599.
Ma, T., et al. 2002. J. Clin. Invest.110, 1651.

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