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Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300.

Synonym: Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

  • CAS Number 1403-36-7

  • Empirical Formula (Hill Notation) C31H30N6O6S4

  • Molecular Weight 710.87

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Properties

Quality Level   100
assay   ≥97% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  protect from light
storage conditions   -20C
color   off-white
solubility   DMSO: 5 mg/mL
shipped in   wet ice
InChI   1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3
InChI key   ZRZWBWPDBOVIGQ-UHFFFAOYSA-N

Description

General description

A cell-permeable antimicrobial that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation. Prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and <10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Exhibits no effect on the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.

A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.

A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300.

Packaging

1 mg in Plastic Bag(s)

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Fujimoto, H., et al. 2004. J. Nat. Prod.67, 98.
Kung, A.L., et al. 2004. Cancer Cell6, 33.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
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