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220467 Sigma-Aldrich

2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

Synonym: 2-Chloro-2ʹ-deoxyadenosine - CAS 4291-63-8 - Calbiochem, 2CdA, Cladribine

  • CAS Number 4291-63-8

  • Empirical Formula (Hill Notation) C10H12ClN5O3

  • Molecular Weight 285.69

  •  MDL number MFCD00153939

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +2C to +8C
color   white
solubility   DMSO: 5 mg/mL
shipped in   ambient
InChI   1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChI key   PTOAARAWEBMLNO-KVQBGUIXSA-N

Description

General description

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Other Notes

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

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