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220491 Sigma-Aldrich

InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

The InSolution Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, InSolution Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem

  • CAS Number 516480-79-8

  • Empirical Formula (Hill Notation) C20H14ClN3O2

  • Molecular Weight 363.80

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Properties

Quality Level   100
assay   ≥95% (HPLC)
form   liquid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
  desiccated
  protect from light
storage conditions   -20C
shipped in   ambient

Description

General description

A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Arienti, K. L., et al. 2005. J. Med. Chem.48, 1873.

Safety & Documentation

Safety Information

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