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220551 Sigma-Aldrich

Chloramphenicol - CAS 56-75-7 - Calbiochem

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Synonym: Chloramphenicol - CAS 56-75-7 - Calbiochem

  • CAS Number 56-75-7

  • Empirical Formula (Hill Notation) C11H12Cl2N2O5

  • Molecular Weight 323.13

  •  MDL number MFCD00078159

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Properties

Quality Level   100
assay   ≥97% (by Assay)
form   crystalline powder
mfr. no.   Calbiochem®
storage condition   OK to freeze
storage conditions   +15C to +30C
color   gray to off-white
solubility   water: 2.5 mg/mL
  methanol: 35 mg/mL
  ethanol: soluble
shipped in   ambient
InChI   1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
InChI key   WIIZWVCIJKGZOK-UHFFFAOYSA-N

Description

General description

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Packaging

100, 500 g in Glass bottle

25 g in Plastic ampoule

Biochem/physiol Actions

Potency: ≥970 µg/mg

Primary Target
trasnslation of RNA

Other Notes

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Warning
Hazard statements 
WGK Germany 
WGK 3
Protocols & Articles
Peer-Reviewed Papers
15

References

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