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233183 Millipore

Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

Synonym: Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

  • CAS Number 88416-50-6

  • Empirical Formula (Hill Notation) CH2Cl2Na2O6P2 · 4H2O

  • Molecular Weight 360.92

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Properties

Quality Level   100
assay   ≥97% (titration)
form   solid
mfr. no.   Calbiochem®
storage condition   OK to freeze
  desiccated
storage conditions   +2C to +8C
color   white
solubility   water: 1 mg/mL
shipped in   ambient

Description

General description

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).

A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).

Packaging

10 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: no

Primary Target
Osteoclast-mediated bone resorption

Product does not compete with ATP.

Reversible: no

Target IC50: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

Warning

Toxicity: Standard Handling (A)

Other Notes

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

Safety & Documentation

Safety Information

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