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233480 Sigma-Aldrich

Coagulation Factor XI, Human Plasma

Coagulation Factor XI, Human Plasma, CAS 9013-55-2, is a native coagulation factor XI with two identical polypeptide chains linked by disulfide bond. It is activated to Factor XIa by Factor XIIa.

Synonym: Coagulation Factor XI, Human Plasma

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Properties

Related Categories Auxiliary Proteins, Biochemicals and Reagents, Other, Proteins and Derivatives
Quality Level   100
form   liquid
specific activity activity   ≥170 units/mg protein (clotting assay)
mfr. no.   Calbiochem®
storage condition   OK to freeze
  avoid repeated freeze/thaw cycles
storage conditions   = -70C
shipped in   wet ice

Description

General description

Coagulation Factor XI, Human Plasma, CAS 9013-55-2, is a native coagulation factor XI with two identical polypeptide chains linked by disulfide bond. It is activated to Factor XIa by Factor XIIa.

Native coagulation factor XI from human plasma. Consists of two identical polypeptide chains linked by disulfide bonds, that yield a single band at 80 kDa upon reduction with β-mercaptoethanol. In vivo, Factor XI is activated to Factor XIa by Factor XIIa.

Native coagulation factor XI from human plasma. Consists of two identical polypeptide chains linked by disulfide bonds, that yield a single band at 80,000 on reduction with β-mercaptoethanol. In vivo, Factor XI is activated to Factor XIa by Factor XIIa.

Packaging

100 μg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Analysis Note

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

single band by SDS-PAGE

Safety & Documentation

Safety Information

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